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Journal article

VCAM-1-targeted magnetic resonance imaging reveals subclinical disease in a mouse model of multiple sclerosis.

Abstract:

Diagnosis of multiple sclerosis (MS) currently requires lesion identification by gadolinium (Gd)-enhanced or T(2)-weighted magnetic resonance imaging (MRI). However, these methods only identify late-stage pathology associated with blood-brain barrier breakdown. There is a growing belief that more widespread, but currently undetectable, pathology is present in the MS brain. We have previously demonstrated that an anti-VCAM-1 antibody conjugated to microparticles of iron oxide (VCAM-MPIO) enabl...

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Publication status:
Published

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Publisher copy:
10.1096/fj.11-183772

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology More from this journal
Volume:
25
Issue:
12
Pages:
4415-4422
Publication date:
2011-12-01
DOI:
EISSN:
1530-6860
ISSN:
0892-6638

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