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RYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me3

Abstract:

Polycomb-repressive complex 1 (PRC1) has a central role in the regulation of heritable gene silencing during differentiation and development. PRC1 recruitment is generally attributed to interaction of the chromodomain of the core protein Polycomb with trimethyl histone H3K27 (H3K27me3), catalyzed by a second complex, PRC2. Unexpectedly we find that RING1B, the catalytic subunit of PRC1, and associated monoubiquitylation of histone H2A are targeted to closely overlapping sites in wild-type and...

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Publisher copy:
10.1016/j.cell.2011.12.029

Authors


Journal:
Cell More from this journal
Volume:
148
Issue:
4
Pages:
664-678
Publication date:
2012-02-17
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Language:
English
Pubs id:
pubs:316985
UUID:
uuid:d2aee1cf-3e2a-4359-89f5-401a65e7da56
Local pid:
pubs:316985
Source identifiers:
316985
Deposit date:
2012-12-19

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