Journal article
Cinacalcet corrects hypercalcemia in mice with an inactivating Gα11 mutation
- Abstract:
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Loss-of-function mutations of GNA11, which encodes G-protein subunit α11 (Gα11), a signaling partner for the calcium-sensing receptor (CaSR), result in familial hypocalciuric hypercalcemia type 2 (FHH2). FHH2 is characterized by hypercalcemia, inappropriately normal or raised parathyroid hormone (PTH) concentrations, and normal or low urinary calcium excretion. A mouse model for FHH2 that would facilitate investigations of the in vivo role of Gα11 and the evaluation of calcimimetic drugs, whi...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 2.7MB, Terms of use)
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- Publisher copy:
- 10.1172/jci.insight.96540
Authors
Funding
+ Wellcome Trust
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Funding agency for:
Howles, S
Thakker, R
Grant:
Clinical Training Fellow
Bibliographic Details
- Publisher:
- American Society for Clinical Investigation
- Journal:
- JCI Insight More from this journal
- Volume:
- 2
- Issue:
- 20
- Article number:
- e96540
- Publication date:
- 2017-10-19
- DOI:
- ISSN:
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2379-3708
Item Description
- Language:
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English
- Pubs id:
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pubs:738187
- UUID:
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uuid:d2ac176d-9fe1-4a2f-98c8-7762c4647547
- Local pid:
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pubs:738187
- Deposit date:
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2017-10-23
Terms of use
- Copyright holder:
- Howles et al
- Copyright date:
- 2017
- Notes:
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Copyright © 2017 Howles et al.
This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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