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Short-term starvation of immune deficient Drosophila improves survival to gram-negative bacterial infections.

Abstract:

BACKGROUND: Primary immunodeficiencies are inborn errors of immunity that lead to life threatening conditions. These predispositions describe human immunity in natura and highlight the important function of components of the Toll-IL-1- receptor-nuclear factor kappa B (TIR-NF-kappaB) pathway. Since the TIR-NF-kappaB circuit is a conserved component of the host defence in higher animals, genetically tractable models may contribute ideas for clinical interventions. METHODOLOGY/PRINCIPAL FINDING...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0004490

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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
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Funding agency for:
Cook, PE
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Funding agency for:
Ligoxygakis, P
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Funding agency for:
Ligoxygakis, P
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Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
4
Issue:
2
Pages:
Article: e4490
Publication date:
2009-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:d2a6af61-369b-4cca-bc97-4ab9c71759a0
Source identifiers:
99930
Local pid:
pubs:99930

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