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A comparison of case-control and family-based association methods: the example of sickle-cell and malaria.

Abstract:

There has been much debate about the relative merits of population- and family-based strategies for testing genetic association, yet there is little empirical data that directly compare the two approaches. Here we compare case-control and transmission/disequilibrium test (TDT) study designs using a well-established genetic association, the protective effect of the sickle-cell trait against severe malaria. We find that the two methods give similar estimates of the level of protection (case-con...

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Publication status:
Published

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Authors


Ackerman, H More by this author
Sisay-Joof, F More by this author
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Journal:
Annals of human genetics
Volume:
69
Issue:
Pt 5
Pages:
559-565
Publication date:
2005-09-05
DOI:
EISSN:
1469-1809
ISSN:
0003-4800
URN:
uuid:d2a58550-e638-4e3a-8c69-0103c2d4f82a
Source identifiers:
33220
Local pid:
pubs:33220

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