Low-dose valaciclovir prophylaxis against cytomegalovirus disease in renal transplant recipients.

Journal article

High-dose valaciclovir at up to 8 g/day has been shown to be effective in prophylaxis against cytomegalovirus (CMV) disease in renal transplant recipients. We report our experience with low-dose valaciclovir prophylaxis of up to 3 g/day, adjusted to creatinine clearance. A group of patients at high risk of developing CMV disease who received prophylaxis were selected as the study group. This included all CMV-positive patients who received antilymphocyte therapy (R+, n=20) and all CMV-negative...

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Authors: Reddy, S; Handa, A; Tan, L; Devaney, A; Hughes, D

• Publication status: Published
• Journal: Transplant international : official journal of the European Society for Organ Transplantation
• Volume: 16
• Issue: 10
• Pages: 726-729
• Publication date: 2003-10-01
• DOI: 10.1007/s00147-003-0612-4
• EISSN: 1432-2277
• ISSN: 0934-0874
• Language: English
• Keywords: Postoperative Complications; Cytomegalovirus Infections; Acyclovir; Drug Therapy, Combination; Female; Kidney Transplantation; Adult; Antiviral Agents; Retrospective Studies; Prodrugs; Dose-Response Relationship, Drug; Valine; Tissue Donors; Humans; Immunosuppressive Agents; Reoperation; Living Donors; Male