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Journal article

Th17 cells induce a distinct graft rejection response that does not require IL-17A

Abstract:

IL-17A-producing helper T (Th17) cells have been implicated in the pathogenesis of autoimmune disease, inflammatory bowel disease and graft rejection, however the mechanisms by which they cause tissue damage remain ill-defined. We examined what damage Th17 cell lines could inflict on allogeneic skin grafts in the absence of other adaptive lymphocytes. CD4 Th17 cell lines were generated from two TCR transgenic mouse strains, A1(M).RAG1 and Marilyn, each monospecific for the male antigen Dby....

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Journal:
American Journal of Transplantation
Volume:
12
Issue:
4
Pages:
835-845
Publication date:
2012-04-05
DOI:
EISSN:
1600-6143
ISSN:
1600-6135
URN:
uuid:d2a0995d-3b9d-4106-a46d-102a09fd95e7
Source identifiers:
325278
Local pid:
pubs:325278

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