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Selective tumor necrosis factor receptor I blockade is antiinflammatory and reveals immunoregulatory role of tumor necrosis factor receptor II in collagen-induced arthritis.

Abstract:

OBJECTIVE: Tumor necrosis factor (TNF) signals via 2 receptors, TNFR type I (TNFRI) and TNFRII, with distinct cellular distribution and signaling functions. In rheumatoid arthritis (RA), the net effect of TNFR signaling favors inflammatory responses while inhibiting the activity of regulatory T cells. TNFRII signaling has been shown to promote Treg cell function. To assess the relative contributions of TNFRI and TNFRII signaling to inflammatory and regulatory responses in vivo, we compared th...

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Publication status:
Published

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Publisher copy:
10.1002/art.38755

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Publisher:
John Wiley and Sons Inc.
Journal:
Arthritis and rheumatology (Hoboken, N.J.) More from this journal
Volume:
66
Issue:
10
Pages:
2728-2738
Publication date:
2014-10-01
DOI:
EISSN:
2326-5205
ISSN:
2326-5191
Language:
English
Keywords:
Pubs id:
pubs:471189
UUID:
uuid:d29ca8bc-f41b-402a-acf6-14a445152acb
Local pid:
pubs:471189
Source identifiers:
471189
Deposit date:
2014-07-01

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