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Thesis

Therapeutic targeting of histone H3 lysine 36 trimethylation-deficient cancers

Abstract:

Histone modifications play diverse and essential roles in the maintenance of genome integrity, as evidenced by the frequency at which different histone marks are dysregulated during tumourigenesis. The trimethylation of histone H3 at lysine 36 (H3K36me3) and SETD2, the enzyme solely responsible for this histone mark, are important in many cellular processes and have been reported to be lost or mutated in cancers. Targeting cells that are deficient in H3K36me3 or SETD2 is therefore an attra...

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Division:
MSD
Department:
Oncology
Role:
Author

Contributors

Role:
Supervisor
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Name:
Urology Cancer Research
Funding agency for:
Lopez, K
Grant:
160605-TH
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:d2953ec5-16ef-4fdb-b513-40b1886863f1
Deposit date:
2019-10-21

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