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Genotype-Dependent Effects of COMT Inhibition on Cognitive Function in a Highly-Specific, Novel Mouse Model of Altered COMT Activity.

Abstract:

Catechol-O-methyltransferase (COMT) modulates dopamine levels in the prefrontal cortex (PFC). The human gene contains a polymorphism (Val(158)Met) that alters enzyme activity and influences PFC function. It has also been linked with cognition and anxiety, but findings are mixed. We therefore developed a novel mouse model of altered COMT activity. The human Met allele was introduced into the native mouse COMT gene to produce COMT-Met mice, which were compared to their wild-type littermates. Th...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/npp.2016.119

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Department:
Oxford, MSD, Psychiatry
Role:
Author
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Department:
Oxford, MSD, Psychiatry
Role:
Author
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Department:
Oxford, MSD, Psychiatry
Role:
Author
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Department:
Oxford, MSD, Psychiatry
Role:
Author
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Department:
Oxford, MSD
Role:
Author
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Grant:
Studentships; Senior Fellowship (087736)
Publisher:
Nature Publishing Group Publisher's website
Journal:
Neuropsychopharmacology Journal website
Volume:
41
Issue:
13
Pages:
3060-3069
Publication date:
2016-08-10
Acceptance date:
2016-06-30
DOI:
EISSN:
1740-634X
ISSN:
0893-133X
Pubs id:
pubs:632188
URN:
uri:d28c07f8-035d-4fe1-8c6b-c695357524bc
UUID:
uuid:d28c07f8-035d-4fe1-8c6b-c695357524bc
Local pid:
pubs:632188
Paper number:
13
Language:
English
Keywords:

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