- Abstract:
-
Catechol-O-methyltransferase (COMT) modulates dopamine levels in the prefrontal cortex (PFC). The human gene contains a polymorphism (Val(158)Met) that alters enzyme activity and influences PFC function. It has also been linked with cognition and anxiety, but findings are mixed. We therefore developed a novel mouse model of altered COMT activity. The human Met allele was introduced into the native mouse COMT gene to produce COMT-Met mice, which were compared to their wild-type littermates. Th...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 369.4KB)
-
- Publisher copy:
- 10.1038/npp.2016.119
-
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- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Neuropsychopharmacology Journal website
- Volume:
- 41
- Issue:
- 13
- Pages:
- 3060-3069
- Publication date:
- 2016-08-10
- Acceptance date:
- 2016-06-30
- DOI:
- EISSN:
-
1740-634X
- ISSN:
-
0893-133X
- Pubs id:
-
pubs:632188
- URN:
-
uri:d28c07f8-035d-4fe1-8c6b-c695357524bc
- UUID:
-
uuid:d28c07f8-035d-4fe1-8c6b-c695357524bc
- Local pid:
- pubs:632188
- Paper number:
- 13
- Language:
- English
- Keywords:
- Copyright holder:
- Barkus et al.
- Copyright date:
- 2016
- Notes:
-
© The Author(s) 2016. This work is licensed under a Creative Commons
Attribution 4.0 International License.
Journal article
Genotype-Dependent Effects of COMT Inhibition on Cognitive Function in a Highly-Specific, Novel Mouse Model of Altered COMT Activity.
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