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Seven-year kinetics of RTS, S/AS01-induced anti-CSP antibodies in young Kenyan children

Abstract:

Background RTS,S/AS01, the leading malaria vaccine has been recommended by the WHO for widespread immunization of children at risk. RTS,S/AS01-induced anti-CSP IgG antibodies are associated with the vaccine efficacy. Here, the long-term kinetics of RTS,S/AS01-induced antibodies was investigated. Methods 150 participants were randomly selected from the 447 children who participated in the RTS,S/AS01 phase IIb clinical trial in 2007 from Kilifi-Kenya. Cumulatively, the retrospective follow-up ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12936-021-03961-2

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Role:
Author
ORCID:
0000-0001-7209-4614
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Name:
Medical Research Council
Grant:
MR/P020321/1
Publisher:
BioMed Central
Journal:
Malaria Journal More from this journal
Volume:
20
Article number:
452
Publication date:
2021-12-02
Acceptance date:
2021-10-20
DOI:
EISSN:
1475-2875
Language:
English
Keywords:
Pubs id:
1216237
Local pid:
pubs:1216237
Deposit date:
2021-12-03

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