- Abstract:
-
BACKGROUND: Elderly and frail patients with cancer, although often treated with chemotherapy, are under-represented in clinical trials. We designed FOCUS2 to investigate reduced-dose chemotherapy options and to seek objective predictors of outcome in frail patients with advanced colorectal cancer. METHODS: We undertook an open, 2 × 2 factorial trial in 61 UK centres for patients with previously untreated advanced colorectal cancer who were considered unfit for full-dose chemotherapy. After c...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/s0140-6736(11)60399-1
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- Journal:
- Lancet
- Volume:
- 377
- Issue:
- 9779
- Pages:
- 1749-1759
- Publication date:
- 2011-05-05
- DOI:
- EISSN:
-
1474-547X
- ISSN:
-
0140-6736
- URN:
-
uuid:d269aa67-1bb9-4621-9a98-b6fb3406f445
- Source identifiers:
-
232287
- Local pid:
- pubs:232287
- Language:
- English
- Keywords:
- Copyright date:
- 2011
Journal article
Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial.
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