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Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial.

Abstract:

BACKGROUND: Elderly and frail patients with cancer, although often treated with chemotherapy, are under-represented in clinical trials. We designed FOCUS2 to investigate reduced-dose chemotherapy options and to seek objective predictors of outcome in frail patients with advanced colorectal cancer. METHODS: We undertook an open, 2 × 2 factorial trial in 61 UK centres for patients with previously untreated advanced colorectal cancer who were considered unfit for full-dose chemotherapy. After c...

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Publication status:
Published

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Journal:
Lancet
Volume:
377
Issue:
9779
Pages:
1749-1759
Publication date:
2011-05-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:d269aa67-1bb9-4621-9a98-b6fb3406f445
Source identifiers:
232287
Local pid:
pubs:232287

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