Journal article icon

Journal article

The structure of a chondroitin sulfate-binding domain important in placental malaria.

Abstract:

Adhesive PfEMP1 proteins are displayed on the surface of malaria-infected red blood cells. They play a critical role in the disease, tethering infected cells away from destruction by the spleen and causing many severe symptoms. A molecular understanding of how these domains maintain their binding properties while evading immune detection will be important in developing therapeutics. In malaria of pregnancy, domains from the var2csa-encoded PfEMP1 protein interact with chondroitin sulfate on t...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1074/jbc.c800086200

Authors


Journal:
Journal of biological chemistry More from this journal
Volume:
283
Issue:
32
Pages:
21842-21846
Publication date:
2008-08-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Language:
English
Keywords:
Pubs id:
pubs:196854
UUID:
uuid:d2650893-ba53-409b-9702-105470d61925
Local pid:
pubs:196854
Source identifiers:
196854
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP