Journal article icon

Journal article

Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins.

Abstract:

Beta-lactam antibiotics, including penicillins and cephalosporins, inhibit penicillin-binding proteins (PBPs), which are essential for bacterial cell wall biogenesis. Pathogenic bacteria have evolved efficient antibiotic resistance mechanisms that, in Gram-positive bacteria, include mutations to PBPs that enable them to avoid beta-lactam inhibition. Lactivicin (LTV; 1) contains separate cycloserine and gamma-lactone rings and is the only known natural PBP inhibitor that does not contain a bet...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1038/nchembio.2007.21

Authors


Expand authors...
Journal:
Nature chemical biology
Volume:
3
Issue:
9
Pages:
565-569
Publication date:
2007-09-05
DOI:
EISSN:
1552-4469
ISSN:
1552-4450
URN:
uuid:d25c8e61-dfdc-46f4-87d8-a03bf43c5961
Source identifiers:
40495
Local pid:
pubs:40495

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP