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Detailed analysis of variation at and around mitochondrial position 16189 in a large Finnish cohort reveals no significant associations with early growth or metabolic phenotypes at age 31 years.

Abstract:

CONTEXT: Mitochondrial dysfunction is increasingly implicated in pathogenesis of adult metabolic disease. Rare mitochondrial (mt) DNA mutations impair glucose homeostasis, but the contribution of common variants is unclear. In small studies, variation within the OriB origin of replication (at mt16189 in particular) has been associated with both early growth and adult metabolic phenotypes and may contribute to life-course relationships between the two. OBJECTIVE: The aim was to study a large w...

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Publication status:
Published

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Publisher copy:
10.1210/jc.2007-0702

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Journal:
The Journal of clinical endocrinology and metabolism
Volume:
92
Issue:
8
Pages:
3219-3223
Publication date:
2007-08-05
DOI:
EISSN:
1945-7197
ISSN:
0021-972X
URN:
uuid:d258fa25-dbe1-4037-a01d-1708398e2292
Source identifiers:
22243
Local pid:
pubs:22243

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