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Selective survival of embryos can explain DNA methylation signatures of adverse prenatal environments

Abstract:

An adverse intrauterine environment is associated with long-term physiological changes in offspring. These are believed to be mediated by epigenomic marks, including DNA methylation (DNAm). Changes in DNAm are often interpreted as damage or plastic responses of the embryo. Here, we propose that stochastic DNAm variation, generated during remodeling of the epigenome after fertilization, contributes to DNAm signatures of prenatal adversity through differential survival of embryos. Using a mathe...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.celrep.2018.11.023

Authors


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Funding agency for:
Uller, T
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Grant:
Seventh Framework Programme project IDEAL (259679)
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Publisher:
Cell Press Publisher's website
Journal:
Cell Reports Journal website
Volume:
25
Issue:
10
Pages:
2660-2667
Publication date:
2018-12-04
Acceptance date:
2018-11-02
DOI:
ISSN:
2211-1247
Pubs id:
pubs:952127
URN:
uri:d2464c64-c801-4a3c-b9c2-1aa177bd6ae9
UUID:
uuid:d2464c64-c801-4a3c-b9c2-1aa177bd6ae9
Local pid:
pubs:952127

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