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Journal article

Virus-like glycodendrinanoparticles displaying quasi-equivalent nested polyvalency upon glycoprotein platforms potently block viral infection.

Abstract:

Ligand polyvalency is a powerful modulator of protein-receptor interactions. Host-pathogen infection interactions are often mediated by glycan ligand-protein interactions, yet its interrogation with very high copy number ligands has been limited to heterogenous systems. Here we report that through the use of nested layers of multivalency we are able to assemble the most highly valent glycodendrimeric constructs yet seen (bearing up to 1,620 glycans). These constructs are pure and well-defined...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/ncomms2302

Authors


Ribeiro-Viana, R More by this author
Sánchez-Navarro, M More by this author
Luczkowiak, J More by this author
Koeppe, JR More by this author
Delgado, R More by this author
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European Union More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature communications Journal website
Volume:
3
Pages:
1303
Publication date:
2012-12-05
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
URN:
uuid:d22cdb38-060d-4ac6-88c2-1d705f698750
Source identifiers:
367650
Local pid:
pubs:367650

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