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Journal article

Depletion of CD4+ and CD8+ cells eliminates immunologic memory of thyroiditogenicity in murine experimental autoimmune thyroiditis.

Abstract:

Experimental autoimmune thyroiditis (EAT) develops in genetically susceptible mice after immunization with mouse thyroglobulin (MTg), and is mediated by T cells, both CD4+ and CD8+, infiltrating the thyroid. Previous work showed that depletion of CD4+, but not CD8+, cells with rat monoclonal antibodies (mAbs) interfered with EAT induction. To test if concomitant CD4+ cell depletion and immunization led to EAT resistance, mice were reimmunized at an interval of 15 or 43 days after injection of...

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Publication status:
Published

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Publisher copy:
10.3109/08916939408995691

Authors


Fuller, BE More by this author
Giraldo, AA More by this author
Waldmann, H More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Autoimmunity
Volume:
19
Issue:
3
Pages:
161-168
Publication date:
1994-01-05
DOI:
EISSN:
1607-842X
ISSN:
0891-6934
URN:
uuid:d2250abd-3ae3-4fa9-8c12-d38085dcf29a
Source identifiers:
24956
Local pid:
pubs:24956

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