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Journal article

Differential T cell receptor-mediated signaling in naive and memory CD4 T cells.

Abstract:

Naive and memory CD4 T cells differ in cell surface phenotype, function, activation requirements, and modes of regulation. To investigate the molecular bases for the dichotomies between naive and memory CD4 T cells and to understand how the T cell receptor (TCR) directs diverse functional outcomes, we investigated proximal signaling events triggered through the TCR/CD3 complex in naive and memory CD4 T cell subsets isolated on the basis of CD45 isoform expression. Naive CD4 T cells signal thr...

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Publication status:
Published

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Publisher copy:
10.1002/eji.1830270838

Authors


Farber, DL More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Bottomly, K More by this author
Journal:
European journal of immunology
Volume:
27
Issue:
8
Pages:
2094-2101
Publication date:
1997-08-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:d21178d0-3590-4c52-920c-4aa04097ab43
Source identifiers:
23004
Local pid:
pubs:23004

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