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Functionality or transcriptional noise? Evidence for selection within long noncoding RNAs.

Abstract:

Long transcripts that do not encode protein have only rarely been the subject of experimental scrutiny. Presumably, this is owing to the current lack of evidence of their functionality, thereby leaving an impression that, instead, they represent "transcriptional noise." Here, we describe an analysis of 3122 long and full-length, noncoding RNAs ("macroRNAs") from the mouse, and compare their sequences and their promoters with orthologous sequence from human and from rat. We considered three in...

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Publication status:
Published

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Publisher copy:
10.1101/gr.6036807

Authors


Ponjavic, J More by this author
Ponting, CP More by this author
Journal:
Genome research
Volume:
17
Issue:
5
Pages:
556-565
Publication date:
2007-05-05
DOI:
EISSN:
1549-5469
ISSN:
1088-9051
URN:
uuid:d20f84df-32cc-41d0-84e1-96d5e6aa2b72
Source identifiers:
68311
Local pid:
pubs:68311

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