HLA B37 determines an influenza A virus nucleoprotein epitope recognized by cytotoxic T lymphocytes.

Journal article

Human influenza A virus-specific, cytotoxic T cells have been shown previously to recognize the virus nucleoprotein on infected cells. CTL preparations from four HLA B37-positive donors were shown to recognize a synthetic peptide that corresponded to amino acids 335-349 of the nucleoprotein sequence. Influenza-specific CTL from 10 donors of other HLA types failed to recognize this epitope. CD8+ CTL lines were derived from lymphocytes of two HLA B37-positive donors and used to show that the pe...

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Authors: Mcmichael, A; Gotch, F; Rothbard, J

• Publication status: Published
• Journal: Journal of experimental medicine
• Volume: 164
• Issue: 5
• Pages: 1397-1406
• Publication date: 1986-11-01
• DOI: 10.1084/jem.164.5.1397
• EISSN: 1540-9538
• ISSN: 0022-1007
• Language: English
• Keywords: T-Lymphocytes, Cytotoxic; HLA-B Antigens; Humans; HLA Antigens; Interleukin-2; Epitopes; Phenotype; Nucleoproteins; Cell Line; Viral Proteins; Influenza A virus