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Uncovering the intimate relationship between lipids, cholesterol and GPCR activation

Abstract:

The membrane bilayer has a significant influence over the proteins embedded within it. G protein-coupled receptors (GPCRs) form a large group of membrane proteins with a vast array of critical functions, and direct and indirect interactions with the bilayer are thought to control various essential aspects of receptor function. The presence of cholesterol, in particular, has been the focus of a number of recent studies, with varying receptor-dependent effects reported. However, the possibility...

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Publisher copy:
10.1016/j.sbi.2011.09.007

Authors


Journal:
Current Opinion in Structural Biology
Volume:
21
Issue:
6
Pages:
802-807
Publication date:
2011-12-05
DOI:
EISSN:
1879-033X
ISSN:
0959-440X
URN:
uuid:d20bf32e-789c-41c0-b66a-1cca9f220dc2
Source identifiers:
221536
Local pid:
pubs:221536
Language:
English

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