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Biological consequences of radiation-induced DNA damage: Relevance to radiotherapy

Abstract:

DNA damage of exposed tumour tissue leading to cell death is one of the detrimental effects of ionising radiation that is exploited, with beneficial consequences, for radiotherapy. The pattern of the discrete energy depositions during passage of the ionising track of radiation defines the spatial distribution of lesions induced in DNA with a fraction of the DNA damage sites containing clusters of lesions, formed over a few nanometres, against a background of endogenously induced individual le...

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Publisher copy:
10.1016/j.clon.2013.06.007

Authors


Folkes, LK More by this author
O'Neill, P More by this author
Journal:
Clinical Oncology
Volume:
25
Issue:
10
Pages:
578-585
Publication date:
2013-10-05
DOI:
EISSN:
1433-2981
ISSN:
0936-6555
URN:
uuid:d2056977-e0f5-4b1e-9106-9af1f71bd777
Source identifiers:
425758
Local pid:
pubs:425758

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