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Biological consequences of radiation-induced DNA damage: Relevance to radiotherapy

Abstract:

DNA damage of exposed tumour tissue leading to cell death is one of the detrimental effects of ionising radiation that is exploited, with beneficial consequences, for radiotherapy. The pattern of the discrete energy depositions during passage of the ionising track of radiation defines the spatial distribution of lesions induced in DNA with a fraction of the DNA damage sites containing clusters of lesions, formed over a few nanometres, against a background of endogenously induced individual le...

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Publisher copy:
10.1016/j.clon.2013.06.007

Authors


Journal:
Clinical Oncology
Volume:
25
Issue:
10
Pages:
578-585
Publication date:
2013-10-01
DOI:
EISSN:
1433-2981
ISSN:
0936-6555
Source identifiers:
425758
Language:
English
Keywords:
Pubs id:
pubs:425758
UUID:
uuid:d2056977-e0f5-4b1e-9106-9af1f71bd777
Local pid:
pubs:425758
Deposit date:
2013-12-11

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