Data and Codes for JRSI publication, " Fluid and Solute Transport across the Retinal Pigment Epithelium: a Theoretical Model"

Dvoriashyna, M

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Data and Codes for JRSI publication, " Fluid and Solute Transport across the Retinal Pigment Epithelium: a Theoretical Model"

Documentation:: Codes to support the publication entitled Fluid and Solute Transport across the Retinal Pigment Epithelium: a Theoretical Model by MARIIA DVORIASHYNA, ALEXANDER J. E. FOSS, EAMONN A. GAFFNEY and RODOLFO REPETTO to be published in J. Royal Society Interface 2020 Paper abstract; The retina is composed of two main layers; the neuroretina and the retinal pigment epithelium (RPE) and they are separated by a potential gap termed the sub-retinal space (SRS). Accumulation of ﬂuid in the SRS will result in a retinal detachment. A key function of the RPE is to prevent ﬂuid accumulation in the SRS by actively pumping ﬂuid from this space to the choroid. We have developed a mathematical model of this process that incorporates the transport of seven chemical species: Na+, K+, Cl−, HCO3−, H+, CO2 and H2CO3. This allows us to estimate solute and water ﬂuxes and to understand the role of the different membrane ion channels. We have performed a global sensitivity analysis, using the extended Fourier Amplitude Sensitivity Test (eFAST) to investigate the relative importance of parameters in generating the model outputs. The model predicts that ﬂow across the RPE is driven by an osmotic gradient in the cleft gap between adjacent cells. Moreover, the model predicts how water ﬂux is modiﬁed in response to inhibition of membrane ion channels and carbonic anhydrase. It provides a possible explanation for how carbonic anhydrase inhibitors, which are used clinically to prevent ﬂuid accumulation in the SRS, may be acting.

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APA Style

Dvoriashyna, M. (2019). Data and Codes for JRSI publication, " Fluid and Solute Transport across the Retinal Pigment Epithelium: a Theoretical Model". University of Oxford.

MLA Style

Dvoriashyna, M. Data and Codes for JRSI Publication, " Fluid and Solute Transport across the Retinal Pigment Epithelium: a Theoretical Model". University of Oxford, 2019.

Chicago Style

Dvoriashyna, M. 2019. “Data and Codes for JRSI Publication, " Fluid and Solute Transport across the Retinal Pigment Epithelium: a Theoretical Model.’” University of Oxford.
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