The microphthalmia-associated transcription factor Mitf interacts with beta-catenin to determine target gene expression.

Journal article

Commitment to the melanocyte lineage is characterized by the onset of expression of the microphthalmia-associated transcription factor (Mitf). This transcription factor plays a fundamental role in melanocyte development and maintenance and seems to be crucial for the survival of malignant melanocytes. Furthermore, Mitf has been shown to be involved in cell cycle regulation and to play important functions in self-renewal and maintenance of melanocyte stem cells. Although little is known about ...

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Authors: Schepsky, A; Bruser, K; Gunnarsson, G; Goodall, J; Hallsson, J

• Publication status: Published
• Journal: Molecular and cellular biology
• Volume: 26
• Issue: 23
• Pages: 8914-8927
• Publication date: 2006-12-01
• DOI: 10.1128/mcb.02299-05
• EISSN: 1098-5549
• ISSN: 0270-7306
• Language: English
• Keywords: Amino Acid Sequence; Microphthalmia-Associated Transcription Factor; Gene Expression; Protein Structure, Tertiary; Promoter Regions, Genetic; Melanocytes; COS Cells; Sequence Homology, Amino Acid; Recombinant Fusion Proteins; beta Catenin; Animals; Cell Line; Green Fluorescent Proteins; Signal Transduction; Transfection; Models, Biological; Cercopithecus aethiops; Cell Lineage; Wnt Proteins; Cell Proliferation; Molecular Sequence Data; Transcription, Genetic; Genes, Reporter; Humans; Luciferases; Glutathione Transferase