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Genome-wide functional analysis of Plasmodium protein phosphatases reveals key regulators of parasite development and differentiation.

Abstract:

Reversible protein phosphorylation regulated by kinases and phosphatases controls many cellular processes. Although essential functions for the malaria parasite kinome have been reported, the roles of most protein phosphatases (PPs) during Plasmodium development are unknown. We report a functional analysis of the Plasmodium berghei protein phosphatome, which exhibits high conservation with the P. falciparum phosphatome and comprises 30 predicted PPs with differential and distinct expression p...

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Publication status:
Published

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Publisher copy:
10.1016/j.chom.2014.05.020

Authors


Guttery, DS More by this author
Ramaprasad, A More by this author
Ferguson, DJ More by this author
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Publisher:
Cell Press
Journal:
Cell host and microbe
Volume:
16
Issue:
1
Pages:
128-140
Publication date:
2014-07-05
DOI:
EISSN:
1934-6069
ISSN:
1931-3128
URN:
uuid:d1e1c838-b292-43e7-a7d6-40ed96ce8c2f
Source identifiers:
476050
Local pid:
pubs:476050
Language:
English

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