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The meaning of death: evolution and ecology of apoptosis in protozoan parasites.

Abstract:

The discovery that an apoptosis-like, programmed cell death (PCD) occurs in a broad range of protozoan parasites offers novel therapeutic tools to treat some of the most serious infectious diseases of humans, companion animals, wildlife, and livestock. Whilst apoptosis is an essential part of normal development, maintenance, and defence in multicellular organisms, its occurrence in unicellular parasites appears counter-intuitive and has proved highly controversial: according to the Darwinian ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.ppat.1002320

Authors


Pollitt, LC More by this author
Colegrave, N More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
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Funding agency for:
Gardner, A
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Funding agency for:
Gardner, A
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Funding agency for:
Gardner, A
Wellcome Trust More from this funder
National Eye Research Centre More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS pathogens Journal website
Volume:
7
Issue:
12
Pages:
e1002320
Publication date:
2011-12-05
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
URN:
uuid:d1dce3da-b747-4169-8673-d9a37d22251b
Source identifiers:
246631
Local pid:
pubs:246631

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