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The CST complex mediates end protection at double-strand breaks and promotes PARP inhibitor sensitivity in BRCA1-deficient cells

Abstract:

Selective elimination of BRCA1-deficient cells by inhibitors of poly(ADP-ribose) polymerase (PARP) is a prime example of the concept of synthetic lethality in cancer therapy. This interaction is counteracted by the restoration of BRCA1-independent homologous recombination through loss of factors such as 53BP1, RIF1, and REV7/MAD2L2, which inhibit end resection of DNA double-strand breaks (DSBs). To identify additional factors involved in this process, we performed CRISPR/SpCas9-based loss-of-...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.celrep.2018.04.046

Authors


Barazas, M More by this author
Annunziato, S More by this author
Pettitt, SJ More by this author
de Krijger, I More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
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Grant:
National Roadmap Grant for Large-Scale Research Facilities
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Publisher:
Elsevier Publisher's website
Journal:
Cell Reports Journal website
Volume:
23
Issue:
7
Pages:
2107-2118
Publication date:
2018-05-15
Acceptance date:
2018-04-11
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Pubs id:
pubs:848164
URN:
uri:d1ccdf9b-044a-4271-b438-e7a58848d6e3
UUID:
uuid:d1ccdf9b-044a-4271-b438-e7a58848d6e3
Local pid:
pubs:848164

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