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Subunit dynamics and nucleotide-dependent asymmetry of an AAA(+) transcription complex.

Abstract:

Bacterial enhancer binding proteins (bEBPs) are transcription activators that belong to the AAA(+) protein family. They form higher-order self-assemblies to regulate transcription initiation at stress response and pathogenic promoters. The precise mechanism by which these ATPases utilize ATP binding and hydrolysis energy to remodel their substrates remains unclear. Here we employed mass spectrometry of intact complexes to investigate subunit dynamics and nucleotide occupancy of the AAA(+) dom...

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Publication status:
Published

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Publisher copy:
10.1016/j.jmb.2013.08.018

Authors


Gordiyenko, Y More by this author
Robinson, CV More by this author
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Journal:
Journal of molecular biology
Volume:
426
Issue:
1
Pages:
71-83
Publication date:
2014-01-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:d1c804a7-ad25-451e-9595-d7a84dd5f514
Source identifiers:
431427
Local pid:
pubs:431427

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