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A universally conserved residue in the SUR1 subunit of the K ATP channel is essential for translating nucleotide binding at SUR1 into channel opening

Abstract:

The sulphonylurea receptor (SUR1) subunit of the ATP-sensitive potassium (K ATP) channel is a member of the ATP-binding cassette (ABC) protein family. Binding of MgADP to nucleotide-binding domain 2 (NBD2) is critical for channel activation. We identified a residue in NBD2 (G1401) that is fully conserved among ABC proteins and whose functional importance is unknown. Homology modelling places G1401 on the outer surface of the protein, distant from the nucleotide-binding site. The ATPase activi...

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Journal:
Journal of Physiology
Volume:
590
Issue:
20
Pages:
5025-5036
Publication date:
2012-10-05
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
URN:
uuid:d1c15471-9d85-4cf2-874c-4d8f7ec96e22
Source identifiers:
356691
Local pid:
pubs:356691
Language:
English

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