Runx1-mediated hematopoietic stem-cell emergence is controlled by a Gata/Ets/SCL-regulated enhancer.

Journal article

The transcription factor Runx1/AML1 is an important regulator of hematopoiesis and is critically required for the generation of the first definitive hematopoietic stem cells (HSCs) in the major vasculature of the mouse embryo. As a pivotal factor in HSC ontogeny, its transcriptional regulation is of high interest but is largely undefined. In this study, we used a combination of comparative genomics and chromatin analysis to identify a highly conserved 531-bp enhancer located at position + 23....

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Authors: Nottingham, W; Jarratt, A; Burgess, M; Speck, C; Cheng, J

• Publication status: Published
• Journal: Blood
• Volume: 110
• Issue: 13
• Pages: 4188-4197
• Publication date: 2007-12-01
• DOI: 10.1182/blood-2007-07-100883
• EISSN: 1528-0020
• ISSN: 0006-4971
• Language: English
• Keywords: Proto-Oncogene Proteins; Animals; Embryo, Mammalian; Core Binding Factor Alpha 2 Subunit; Adaptor Proteins, Signal Transducing; Transcription, Genetic; GATA2 Transcription Factor; Metalloproteins; DNA-Binding Proteins; Multiprotein Complexes; LIM Domain Proteins; Enhancer Elements, Genetic; Hematopoietic Stem Cells; Proto-Oncogene Protein c-ets-1; Mice; Basic Helix-Loop-Helix Transcription Factors