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Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism

Abstract:

Vps34 PI3K is thought to be the main producer of phosphatidylinositol-3-monophosphate, a lipid that controls intracellular vesicular trafficking. The organismal impact of systemic inhibition of Vps34 kinase activity is not completely understood. Here we show that heterozygous Vps34 kinase-dead mice are healthy and display a robustly enhanced insulin sensitivity and glucose tolerance, phenotypes mimicked by a selective Vps34 inhibitor in wild-type mice. The underlying mechanism of insulin sens...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41467-017-01969-4

Authors


Bilanges, B More by this author
Alliouachene, S More by this author
Morelli, D More by this author
More by this author
ORCID:
0000-0002-3006-3577
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Wellcome Trust More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
8
Issue:
1
Pages:
Article: 1804
Publication date:
2017-11-27
Acceptance date:
2017-10-30
DOI:
ISSN:
2041-1723
Pubs id:
pubs:809112
URN:
uri:d1ba0deb-3032-42de-a4a9-fc8581013c88
UUID:
uuid:d1ba0deb-3032-42de-a4a9-fc8581013c88
Local pid:
pubs:809112
Language:
English

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