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Biological activity, membrane-targeting modification, and crystallization of soluble human decay accelerating factor expressed in E. coli.

Abstract:

Decay-accelerating factor (DAF, CD55) is a glycophosphatidyl inositol-anchored glycoprotein that regulates the activity of C3 and C5 convertases. In addition to understanding the mechanism of complement inhibition by DAF through structural studies, there is also an interest in the possible therapeutic potential of the molecule. In this report we describe the cloning, expression in Escherichia coli, isolation and membrane-targeting modification of the four short consensus repeat domains of sol...

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Publication status:
Published

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Publisher copy:
10.1110/ps.03455604

Authors


Lukacik, P More by this author
Steward, M More by this author
Giddings, N More by this author
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Journal:
Protein science : a publication of the Protein Society
Volume:
13
Issue:
9
Pages:
2406-2415
Publication date:
2004-09-05
DOI:
EISSN:
1469-896X
ISSN:
0961-8368
URN:
uuid:d1b907a3-72a7-47ba-a8b2-fec362bfc35f
Source identifiers:
3462
Local pid:
pubs:3462

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