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A novel color change mechanism for breast cancer biomarker detection: naphthoquinones as specific ligands of human arylamine N-acetyltransferase 1

Abstract:

Human arylamine N-acetyltransferase 1 (hNAT1) has become an attractive potential biomarker for estrogen-receptor-positive breast cancers. We describe here the mechanism of action of a selective non-covalent colorimetric biosensor for the recognition of hNAT1 and its murine homologue, mNat2, over their respective isoenzymes, leading to new opportunities in diagnosis. On interaction with the enzyme, the naphthoquinone probe undergoes an instantaneous and striking visible color change from red t...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0070600

Authors


Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
8
Issue:
8
Pages:
e70600
Publication date:
2013-08-05
Acceptance date:
2013-05-30
DOI:
EISSN:
1932-6203
Source identifiers:
417304
Language:
English
Keywords:
UUID:
uuid:d19d86fc-e8cc-49b8-8d60-6d9c5896184d
Local pid:
pubs:417304
Deposit date:
2013-11-16

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