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The CcmC–CcmE interaction during cytochrome c maturation by System I is driven by protein–protein and not protein–heme contacts

Abstract:

Cytochromes c are ubiquitous proteins, essential for life in most organisms. Their distinctive characteristic is the covalent attachment of heme to their polypeptide chain. This post-translational modification is performed by a dedicated protein system, which in many Gram-negative bacteria and plant mitochondria is a nine-protein apparatus (CcmA–I) called System I. Despite decades of study, mechanistic understanding of the protein–protein interactions in this highly complex maturation machine...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1074/jbc.ra118.005024

Authors


Shevket, SH More by this author
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ORCID:
0000-0003-3414-1461
Cartwright, JL More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Oxford college:
St Edmund Hall
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Grant:
MR/M009505/1 to D.A.I.M.
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Grant:
Postdoc Mobility Fellowship P2LAP3_155109 (to D.G.),
Publisher:
American Society for Biochemistry and Molecular Biology Publisher's website
Journal:
Journal of Biological Chemistry Journal website
Volume:
293
Issue:
43
Pages:
16778-16790
Publication date:
2018-09-11
Acceptance date:
2018-09-11
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Pubs id:
pubs:920877
URN:
uri:d199f64c-1da3-4d9f-b33d-f140535e2130
UUID:
uuid:d199f64c-1da3-4d9f-b33d-f140535e2130
Local pid:
pubs:920877

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