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Modulation of T cell activation by stomatin-like protein 2.

Abstract:

T cell activation through the Ag receptor (TCR) requires sustained signaling from signalosomes within lipid raft microdomains in the plasma membrane. In a proteomic analysis of lipid rafts from human T cells, we identified stomatin-like protein (SLP)-2 as a candidate molecule involved in T cell activation through the Ag receptor. In this study, we show that SLP-2 expression in human primary lymphocytes is up-regulated following in vivo and ex vivo activation. In activated T cells, SLP-2 inter...

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Publisher copy:
10.4049/jimmunol.181.3.1927

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Journal:
Journal of Immunology
Volume:
181
Issue:
3
Pages:
1927-1936
Publication date:
2008-08-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
426312
Language:
English
Keywords:
Pubs id:
pubs:426312
UUID:
uuid:d1945643-4cbc-4588-8058-3646fd4d0591
Local pid:
pubs:426312
Deposit date:
2014-07-10

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