Cytosine arabinoside affects the heat and capsaicin receptor TRPV1 localisation and sensitivity in human sensory neurons.

Journal article

BACKGROUND: Cytosine arabinoside (Ara C) is a useful chemotherapy agent, used for treating acute myeloid leukaemia, although it may be associated with side effects including painful neuropathy. It is also used for in vitro neuronal studies to limit the proliferation of non-neuronal cells and thereby select nondividing neuronal cells. We studied the effects of Ara C on human dorsal root ganglion (DRG) neurons, especially the expression and sensitivity of the ion channel TRPV1, which responds ...

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Authors: Anand, U; Otto, W; Bountra, C; Chessell, I; Sinisi, M

• Publication status: Published
• Journal: Journal of neuro-oncology
• Volume: 89
• Issue: 1
• Pages: 1-7
• Publication date: 2008-08-01
• DOI: 10.1007/s11060-008-9585-6
• EISSN: 1573-7373
• ISSN: 0167-594X
• Language: English
• Keywords: Time Factors; Humans; Cell Survival; GAP-43 Protein; Cell Division; Calcium; Dose-Response Relationship, Drug; Cell Membrane; Ionomycin; Capsaicin; Cells, Cultured; Peripheral Nervous System Diseases; Antimetabolites, Antineoplastic; Cytarabine; Sensory System Agents; TRPV Cation Channels; Ganglia, Spinal; Adult; Neurons, Afferent