Estimating glomerular filtration rate in HIV-infected adults in Africa: comparison of Cockcroft-Gault and Modification of Diet in Renal Disease formulae.

Journal article

BACKGROUND: Cockcroft-Gault (CG) and Modification of Diet in Renal Disease (MDRD) formulae are recommended for glomerular filtration rate (GFR) estimation, but neither has been validated or directly compared longitudinally in HIV-infected patients or in Africa. METHODS: We investigated differences between formulae in baseline GFR, GFR changes and incidence of impaired GFR after initiation of antiretroviral therapy (ART) in 3,316 HIV-infected adults in Africa, considering sex, age, body mass i...

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Authors: Stöhr, W; Walker, A; Munderi, P; Tugume, S; Gilks, C

• Publication status: Published
• Journal: Antiviral therapy
• Volume: 13
• Issue: 6
• Pages: 761-770
• Publication date: 2008-01-01
• EISSN: 2040-2058
• ISSN: 1359-6535
• Language: English
• Keywords: Patient Selection; Glomerular Filtration Rate; DART Trial; Antiretroviral Therapy, Highly Active; Dietary Carbohydrates; Creatinine; Randomized Controlled Trials as Topic; AIDS-Associated Nephropathy; Female; Algorithms; Zimbabwe; Sex Factors; Diet; Anti-HIV Agents; Age Factors; Cohort Studies; Humans; Adult; Predictive Value of Tests; Male; Uganda