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A review of preclinical animal models utilised for TB vaccine evaluation in the context of recent human efficacy data

Abstract:

Summary There is an urgent need for an improved TB vaccine. Vaccine development is hindered by the lack of immune correlates and uncertain predictive value of preclinical animal models. As data become available from human efficacy trials, there is an opportunity to evaluate the predictive value of the criteria used to select candidate vaccines. Here we review the efficacy in animal models of the MVA85A candidate vaccine in light of recent human efficacy data and propose refinements to the pre...

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Publisher copy:
10.1016/j.tube.2013.11.003

Authors


McShane, H More by this author
Williams, A More by this author
Journal:
Tuberculosis
Volume:
94
Issue:
2
Pages:
105-110
Publication date:
2014-03-05
DOI:
EISSN:
1873-281X
ISSN:
1472-9792
URN:
uuid:d14af01a-a6e2-4fc1-9f3d-f55295b2cc46
Source identifiers:
450188
Local pid:
pubs:450188
Language:
English
Keywords:

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