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Disulfide-based poly(amido amine)s for siRNA delivery: effects of structure on siRNA complexation, cellular uptake, gene silencing and toxicity.

Abstract:

PURPOSE: RNA interference (RNAi) is a process by which small interfering RNAs (siRNA) induce sequence-specific gene silencing. Therefore, siRNA is an emerging promise as a novel therapeutic. In order to realize the high expectations for therapeutic applications, efficient delivery systems for siRNA are necessary. METHODS: In this study, a new series of biodegradable poly(amido amine)s with disulfide linkages in the backbone was synthesized out of N,N'-cystaminebisacrylamide (CBA), 4-amino-1-...

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Publisher copy:
10.1007/s11095-010-0344-y

Authors

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Pharmaceutical research More from this journal
Volume:
28
Issue:
5
Pages:
1013-1022
Publication date:
2011-05-01
DOI:
EISSN:
1573-904X
ISSN:
0724-8741
Language:
English
Keywords:
Pubs id:
pubs:345856
UUID:
uuid:d146718e-f8a4-4461-912a-6063fe8c2d76
Local pid:
pubs:345856
Source identifiers:
345856
Deposit date:
2013-11-16

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