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Regulation of insulin granule exocytosis

Abstract:

Insulin is stored in secretory granules within the pancreatic beta cell. The release of insulin requires the fusion of the secretory granule with the plasma membrane and the discharge of the granule contents into the extracellular space. Insulin secretion follows a characteristic biphasic time course consisting of a rapid but transient 1st phase followed by a slowly developing and sustained 2nd phase. Because type 2 diabetes involves defects of insulin secretion, manifested as a loss of 1st p...

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Publisher copy:
10.1007/978-4-431-75452-7_9

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Role:
Author
Publisher:
Springer Japan
Pages:
147-176
Host title:
Pancreatic Beta Cell in Health and Disease
Publication date:
2008-01-01
DOI:
URN:
uuid:d143bc54-c5f4-4627-9d29-c51e61771dbd
Source identifiers:
466860
Local pid:
pubs:466860
ISBN:
9784431754510

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