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A rapid-response humoral vaccine platform exploiting pre-existing non-cognate populations of anti-vaccine or anti-viral CD4+ T helper cells to confirm B cell activation

Abstract:

The need for CD4+ T cell responses to arise de novo following vaccination can limit the speed of B cell responses. Populations of pre-existing vaccine-induced or anti-viral CD4+ T cells recognising distinct antigens could be exploited to overcome this limitation. We hypothesise that liposomal vaccine particles encapsulating epitopes that are recognised, after processing and B cell MHCII presentation, by pre-existing CD4+ T cells will exploit this pre-existing T cell help and result in improve...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0166383

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Department:
Oxford, MSD, Oncology
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Department:
Oxford, MSD, Oncology
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Department:
St Cross College
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Department:
Oxford, MSD, Pathology Dunn School
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Department:
Oxford, MSD, Oncology
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Funding agency for:
Hills, T
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS One Journal website
Volume:
11
Issue:
11
Pages:
Article: e0166383
Publication date:
2016
DOI:
ISSN:
1932-6203
Pubs id:
pubs:663965
URN:
uri:d1336ea3-3269-4c62-94a9-c5403f51129d
UUID:
uuid:d1336ea3-3269-4c62-94a9-c5403f51129d
Local pid:
pubs:663965
Language:
English
Keywords:

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