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Journal article

Pharmacological characterization of the putative cADP-ribose receptor.

Abstract:

cADP-ribose (cADPR), a naturally occurring metabolite of NAD(+), has been shown to be an important regulator of intracellular Ca(2+) release. Considerable evidence suggests that cADPR is the endogenous modulator of the ryanodine receptor (RyR), which mediates Ca(2+)-induced Ca(2+) release (CICR). Indeed, cADPR-mediated Ca(2+) release is subject to functional regulation by other modulators of CICR, including Ca(2+), caffeine and calmodulin. However, the underlying basis behind the effect of su...

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Publication status:
Published

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Publisher copy:
10.1042/0264-6021:3590451

Authors


Thomas, JM More by this author
Masgrau, R More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology, BHF Centre of Research Excellence
Journal:
The Biochemical journal
Volume:
359
Issue:
Pt 2
Pages:
451-457
Publication date:
2001-10-05
DOI:
EISSN:
1470-8728
ISSN:
0264-6021
URN:
uuid:d125ae5c-023f-4229-8682-57a912a1748c
Source identifiers:
106265
Local pid:
pubs:106265

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