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A torque-based method demonstrates increased rigidity in Parkinson's disease during low-frequency stimulation.

Abstract:

Low-frequency oscillations in the basal ganglia are prominent in patients with Parkinson's disease off medication. Correlative and more recent interventional studies potentially implicate these rhythms in the pathophysiology of Parkinson's disease. However, effect sizes have generally been small and limited to bradykinesia. In this study, we investigate whether these effects extend to rigidity and are maintained in the on-medication state. We studied 24 sides in 12 patients on levodopa during...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1007/s00221-012-3107-7

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Institution:
University of Oxford
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Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
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Author
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Institution:
University of Oxford
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Author
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Institution:
University of Oxford
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Author
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Funding agency for:
Little, S
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Publisher:
Springer-Verlag Publisher's website
Journal:
Experimental brain research Journal website
Volume:
219
Issue:
4
Pages:
499-506
Publication date:
2012-06-05
DOI:
EISSN:
1432-1106
ISSN:
0014-4819
URN:
uuid:d11ff8b7-d308-484d-8a24-35d82253476a
Source identifiers:
332808
Local pid:
pubs:332808

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