Predicting epistasis: an experimental test of metabolic control theory with bacterial transcription and translation.
Epistatic interactions between mutations are thought to play a crucial role in a number of evolutionary processes, including adaptation and sex. Evidence for epistasis is abundant, but tests of general theoretical models that can predict epistasis are lacking. In this study, I test the ability of metabolic control theory to predict epistasis using a novel experimental approach that combines phenotypic and genetic perturbations of enzymes involved in gene expression and protein synthesis in th...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date: