- Abstract:
-
Epistatic interactions between mutations are thought to play a crucial role in a number of evolutionary processes, including adaptation and sex. Evidence for epistasis is abundant, but tests of general theoretical models that can predict epistasis are lacking. In this study, I test the ability of metabolic control theory to predict epistasis using a novel experimental approach that combines phenotypic and genetic perturbations of enzymes involved in gene expression and protein synthesis in th...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1111/j.1420-9101.2009.01888.x
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- Journal:
- Journal of evolutionary biology
- Volume:
- 23
- Issue:
- 3
- Pages:
- 488-493
- Publication date:
- 2010-03-05
- DOI:
- EISSN:
-
1420-9101
- ISSN:
-
1010-061X
- URN:
-
uuid:d11dad39-aa2c-4737-9880-9e148ad84054
- Source identifiers:
-
209913
- Local pid:
- pubs:209913
- Copyright date:
- 2010
Journal article
Predicting epistasis: an experimental test of metabolic control theory with bacterial transcription and translation.
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