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Predicting epistasis: an experimental test of metabolic control theory with bacterial transcription and translation.

Abstract:

Epistatic interactions between mutations are thought to play a crucial role in a number of evolutionary processes, including adaptation and sex. Evidence for epistasis is abundant, but tests of general theoretical models that can predict epistasis are lacking. In this study, I test the ability of metabolic control theory to predict epistasis using a novel experimental approach that combines phenotypic and genetic perturbations of enzymes involved in gene expression and protein synthesis in th...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Journal:
Journal of evolutionary biology
Volume:
23
Issue:
3
Pages:
488-493
Publication date:
2010-03-05
DOI:
EISSN:
1420-9101
ISSN:
1010-061X
URN:
uuid:d11dad39-aa2c-4737-9880-9e148ad84054
Source identifiers:
209913
Local pid:
pubs:209913

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