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Journal article

The small non-coding vault RNA1-1 acts as a riboregulator of autophagy

Abstract:

Vault RNAs (vtRNA) are small non-coding RNAs transcribed by RNA polymerase III found in many eukaryotes. Although they have been linked to drug resistance, apoptosis, and viral replication, their molecular functions remain unclear. Here, we show that vault RNAs directly bind the autophagy receptor sequestosome-1/p62 in human and murine cells. Overexpression of human vtRNA1-1 inhibits, while its antisense LNA-mediated knockdown enhances p62-dependent autophagy. Starvation of cells reduces the ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.cell.2019.01.030

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Publisher:
Cell Press Publisher's website
Journal:
Cell Journal website
Volume:
176
Issue:
5
Pages:
1054-1067
Publication date:
2019-02-14
Acceptance date:
2019-01-16
DOI:
ISSN:
0092-8674
Source identifiers:
935439
Language:
English
Keywords:
Pubs id:
pubs:935439
UUID:
uuid:d11c508e-2b83-4361-b438-92fd01ac6770
Local pid:
pubs:935439
Deposit date:
2019-01-14

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