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Journal article

Using phenotypic heterogeneity to increase the power of genome-wide association studies: application to age at onset of ischaemic stroke subphenotypes.

Abstract:

Genome-wide association studies (GWAS) have been successful in identifying common variants related to complex disorders. However, some disorders have proved resistant to this strategy with few associations confirmed, despite evidence from twin and family studies of a genetic component. Sophisticated strategies that account for phenotypic heterogeneity may be required to uncover these genetic contributions. Age at onset is an example of a potential source of this heterogeneity in ischaemic str...

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Publication status:
Published

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Publisher copy:
10.1002/gepi.21729

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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Sub department:
Institute of Biomedical Engineering
Role:
Author
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Journal:
Genetic epidemiology
Volume:
37
Issue:
5
Pages:
495-503
Publication date:
2013-07-01
DOI:
EISSN:
1098-2272
ISSN:
0741-0395
Source identifiers:
406191
Language:
English
Keywords:
Pubs id:
pubs:406191
UUID:
uuid:d1195b2a-77a5-4598-8262-c9557e742820
Local pid:
pubs:406191
Deposit date:
2013-11-17

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