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Dictyostelium discoideum as a model to assess genome stability through DNA repair

Abstract:

Preserving genome integrity through repair of DNA damage is critical for human health and defects in these pathways lead to a variety of pathologies, most notably cancer. The social amoeba Dictyostelium discoideum is remarkably resistant to DNA damaging agents and genome analysis reveals it contains orthologues of several DNA repair pathway components otherwise limited to vertebrates. These include the Fanconi Anaemia DNA inter-strand crosslink and DNA strand break repair pathways. Loss of fu...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fcell.2021.752175

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Oxford college:
University College
Role:
Author
National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) More from this funder
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Cell and Developmental Biology Journal website
Volume:
9
Article number:
752175
Publication date:
2021-10-07
Acceptance date:
2021-09-20
DOI:
ISSN:
2296-634X
Language:
English
Keywords:
Pubs id:
1194210
Local pid:
pubs:1194210
Deposit date:
2021-09-20

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