LuxS: Its role in central metabolism and the in vitro synthesis of 4-hydroxy-5-methyl-3(2H)-furanone

Journal article

Many bacteria produce extracellular molecules which function in cell-to-cell communication. One of these molecules, autoinducer 2 (Al-2), was first described as an extracellular signal produced by Vibrio harveyi to control luciferase expression. Subsequently, a number of bacteria have been shown to possess Al-2 activity in their culture supernatants, and bear the luxS gene product, which is required for Al-2 synthesis. In Porphyromonas gingivalis, luxS and pfs, encoding a 5′-methylthioadenosi...

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Authors: Winzer, K; Hardie, K; Burgess, N; Doherty, N; Kirke, D

• Journal: Microbiology
• Volume: 148
• Issue: 4
• Pages: 909-922
• Publication date: 2002-01-01
• ISSN: 1350-0872
• Language: English
• Keywords: S-ribosyl-homocysteine-cleavage enzyme; S-adenosylhomocysteine; S-ribosylhomocysteine; AI-2; Quorum sensing