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Is a raised bicarbonate, without hypercapnia, part of the physiologic spectrum of obesity-related hypoventilation?

Abstract:

BACKGROUND: Obesity hypoventilation syndrome (OHS) conventionally includes awake hypercapnia, but an isolated raised bicarbonate, even in the absence of awake hypercapnia, may represent evidence of "early" OHS. We investigated whether such individuals exhibit certain features characteristic of established OHS. METHODS: Obese subjects (BMI greater than 30 kg/m(2)) were identified from a variety of sources and divided into those with (1) normal blood gas measurements and normal acid-base balanc...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1378/chest.14-1279

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Name:
Oxford Radcliffe Hospital Charitable Funds
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Name:
Oxford Health Services Research Committee
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Name:
Oxford Biomedical Research Centre
Publisher:
American College of Chest Physicians
Journal:
Chest More from this journal
Volume:
147
Issue:
2
Pages:
362-368
Publication date:
2015-02-01
DOI:
EISSN:
1931-3543
ISSN:
0012-3692
Language:
English
Keywords:
Pubs id:
pubs:477797
UUID:
uuid:d1067612-d4ea-41a5-a655-bdec0eb5e264
Local pid:
pubs:477797
Source identifiers:
477797
Deposit date:
2015-11-24

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